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PhD Researcher – Liquid Biopsy Biomarkers for Predicting Pancreatic Cancer Progression in the cross-border HBP Cancer Lab (University Medical Center Groningen / University Medicine Oldenburg)

Carl von Ossietzky Universität Oldenburg -
Oldenburg

Jetzt bewerben

Details zur Stelle

Vollzeit
vor 9 Tagen

Leistungen

Flexible Arbeitszeiten

Qualifikationen

Biologie
Molekularbiologie
Doktorat
R
Forschungserfahrung
Master
Python
Niederländisch

Vollständige Stellenbeschreibung

Paygrade

E13 TV-L

Working Hours

100% (suitable for part-time)

Institution

Department of Human Medicine (School VI of Medicine and Health Sciences)

Location

Oldenburg (Oldb), Groningen

Application Deadline

26.07.2026

First day of work

01.10.2026

Limited

2 years in Groningen + 2 years in Oldenburg

About us

Join a cutting-edge cross-border research initiative in translational pancreatic oncology, bridging two leading university medical centers: the University Medical Center Groningen (UMCG) and the University Medicine Oldenburg (UMO). Our cross-border HBP Cancer Lab focuses on fundamental and translational research in pancreatic cancer, combining liquid biopsy technologies, stromal biology, and tumor immunology.

UMCG and UMO are both leading university medical centers in their respective countries, forming a unique cross-border partnership between the Netherlands and Germany. Together, they provide access to state-of-the-art research infrastructure including single-cell omics platforms, imaging, and biobanking facilities, as well as complementary scientific expertise spanning liquid biopsy technologies, stromal biology, and tumor immunology in pancreatic cancer.

The position is based primarily at UMCG in Groningen, with regular presence in Oldenburg — flexibility and enthusiasm for cross-border work are essential.

This is a unique opportunity to pursue a Double Doctorate awarded jointly by the University of Groningen and the University of Oldenburg, providing outstanding scientific training across two internationally recognized institutions. The position is part of the strategic partnership between the Carl von Ossietzky Universität Oldenburg and the Rijksuniversiteit Groningen, supported in part by a major initiative funded with €22.5 million from Niedersachsen’s Ministry of Science and Culture (MWK) and the Volkswagen Foundation for the project “A Programme for Excellence. Developing Strengths and Building Potential through Interdisciplinary and International Networking”.

Project background

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, characterized not only by aggressive tumor cells but also by a complex tumor microenvironment comprising cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs). Current liquid biopsy approaches focus almost exclusively on tumor-intrinsic markers, leaving the stromal and immune compartments largely unexplored as biomarker sources.

This project aims to develop and validate a novel liquid biopsy biomarker panel that integrates circulating tumor cells, stromal, and immune components to enable personalized diagnosis, prognosis, and treatment monitoring in PDAC patients. The work spans the full translational pipeline — from developing and optimizing cell enrichment and molecular profiling workflows, through single-cell characterization of circulating tumor-associated cell populations, to the integration and clinical validation of a biomarker panel in well-annotated patient cohorts from both UMCG and UMO.

The project builds on an established collaboration between UMCG (Prof. Bansal, Dr. Nijkamp, Dr. Hoogwater) and UMO (Prof. Bockhorn, PD Dr. Meyer), including shared patient cohorts, a joint PDAC database, and existing data and material transfer agreements

Your tasks

Development and optimization of workflows for the isolation and characterization of rare circulating cell populations from blood samples of PDAC patients
Performing single-cell molecular analyses including transcriptomics and targeted proteomics
Bioinformatic data integration and development of predictive biomarker models
Clinical validation of findings using patient cohorts from both institutions
Regular scientific exchange and collaborative work with the partner lab in Oldenburg
Presentation of results at national and international conferences
Contributing to publications and grant applications

Your profile

Required qualifications:

Master of Science in molecular biology, oncology, biomedical sciences, or a related field
Strong background in cell biology and/or translational cancer research
Hands-on experience in laboratory techniques (cell culture, flow cytometry, molecular biology, immunohistochemistry, or similar)
Good command of English (written and spoken)

Preferred qualifications:

Experience with liquid biopsy technologies (circulating tumor cells, cell-free DNA, extracellular vesicles)
Familiarity with single-cell omics methods (scRNA-seq, proteomics)
Basic bioinformatics skills (R, Python, or similar)
Experience working with patient-derived clinical samples
Proficiency in both German and Dutch is a plus
Interest in translational and clinical research
Enthusiasm for cross-border, interdisciplinary collaboration

We offer

A fully funded 4-year PhD position within a dynamic, international cross-border research environment
The unique opportunity to obtain a Double Doctorate from the University of Groningen and the University of Oldenburg
Access to state-of-the-art research infrastructure at both UMCG and UMO, including single-cell omics platforms, biobanking facilities, and clinical sample collections
Supervision by an experienced, interdisciplinary team across both institutions (Prof. Bansal, Prof. Bockhorn, Dr. Meyer, Dr. Nijkamp, Dr. Hoogwater)
Training in liquid biopsy technologies, single-cell biology, and translational oncology within a clinically embedded research environment
Exposure to national and European grant processes (WEAVE, NWO, DAAD, Interreg, ERA4Health)
Payment in accordance with collective bargaining agreements, and 30 days annual leave
A family-friendly environment with flexible working hours and the possibility of mobile work
Access to extensive further education and early career researcher support programmes at both UMCG and UMO

Our standards

The University of Oldenburg is dedicated to increase the percentage of female employees in the field of science. Therefore, female candidates are strongly encouraged to apply. In accordance to § 21 Section 3 NHG, female candidates with equal qualifications will be preferentially considered. Applicants with disabilities will be given preference in case of equal qualification.

Further information

Paygrade
Salary Grade P for 2 years in Groningen
TV-L E13 (100%) for 2 years in Oldenburg

Institution
University Medical Center Groningen (UMCG)
University Medicine Oldenburg (UMO)

Location
Groningen, The Netherlands (HomeBase)
Oldenburg, Germany (regular presence required)

Limited
Employment for 4 years for one’s own academic qualification, the first two years based on a work contract with the University of Groningen, the last two years based on a work contract with the University of Oldenburg

Contact

For further information, please contact: [email protected] or [email protected]

Apply now

Please send your application via e-mail by 26.07.2026 to

[email protected]

Application documents (letter of motivation, curriculum vitae, academic transcripts, and the names of two referees) as a single PDF.

Benefits at University of Oldenburg

30 days vacation

Secure remuneration according to collective agreement

Company pension scheme

Further education opportunities

Flexible working hours

Health management

Remote working

Compatibility of career and family

Support with childcare

University Sports Centre

Certificate Bicycle-friendly employer

Corporate Benefits

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Erweiterte Suche

researcher Jobs in oldenburg, ni

PhD Researcher – Liquid Biopsy Biomarkers for Predicting Pancreatic Cancer Progression in the cross-border HBP Cancer Lab (University Medical Center Groningen / University Medicine Oldenburg)

PhD Position in sport science on the topic: Recognizing the dynamics in talent development: adding another level to the search for the next ice speed skating Olympians

PhD Position / Research Assistant Multi-Objective Wind Farm Control

Joint Research Fellowships

PostDoc Position / Research Assistant Adaptive and Robust Control of Wind Farms