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Scientific Director | tRNA Biotherapeutics

CAREERS AT NLC
Hamburg

Direkt bewerben

Details zur Stelle

Qualifikationen

Biologie
Molekularbiologie
Doktorat
Führungserfahrung

Vollständige Stellenbeschreibung

Scientific Director – tRNA Biotherapeutics

Company Overview

XtRNA Bio is a pioneering biotechnology company developing a proprietary tRNA therapeutic platform for underserved patients with rare genetic diseases and high unmet medical needs. XtRNA Bio is advancing a novel approach to correct translational defects at their root, from discovery through to the clinic — with a focus on meaningful, durable benefit for patients who currently have no options.

XtRNA's proprietary engineering capability enables both elevation and suppression therapy, delivered via synthetic and vectorized formats — giving us access to a broad and expanding universe of treatable diseases.

Role Summary

We are seeking an experienced and visionary Scientific Director to lead and shape XtRNA Bio's scientific strategy and translational research programs.

This role sits at the interface of discovery, preclinical development, and company strategy, working closely with the CEO and broader leadership team. You will drive the advancement of our tRNA platform from proof-of-concept toward IND-enabling studies and early clinical readiness.

The position is primarily remote, with frequent travel to our scientific partners (Radboud University, The Netherlands; Hamburg University, Germany), and flexibility for strategic collaboration across the world.

Location: Remote (Preferred Europe)
Commitment: 80% (approximately)
Compensation: Primarily equity-based, modest base salary until fundraising.

Key Responsibilities

Scientific Leadership & Strategy

Define and execute the scientific vision and R&D roadmap aligned with company milestones (preclinical IND clinical entry)
Lead the development of XtRNA Bio's dual tRNA platform (elevation and suppression modalities)
Translate cutting-edge RNA biology into therapeutic strategies with clinical relevance

Program Leadership

Oversee lead preclinical programs in focus indications (tRNA elevation in neuromuscular diseases, particularly CMT2D, and tRNA suppression in respiratory diseases, particularly CF)
Guide optimization of AAV-tRNA constructs, including vector design, capsid selection, and delivery strategies
Drive development of synthetic tRNA delivery systems to the respiratory tract
Supervise in vivo and in vitro studies, including rodent and NHP models, biomarker development, and functional endpoints
Drive IND-enabling studies, including biodistribution, toxicology, and dose-finding

Platform Expansion

Identify and characterize potential clinical applications of the XtRNA platform
Further develop and optimize our delivery modalities
Engage with relevant academic partners for PoC studies
Develop and nurture a dedicated Scientific Advisory Board

Cross-Functional Collaboration

Partner with teams in:
- CMC and vector manufacturing
- Regulatory and clinical strategy
- Intellectual property and business development
Align scientific execution with fundraising, partnerships, and corporate milestones

Leadership

Establish a culture of scientific excellence, rigor, and innovation
Interface with external collaborators, KOLs, and Scientific Advisory Board members
On the long-term, build, mentor, and inspire a high-performing multidisciplinary R&D team

External Representation

Present scientific progress to investors, partners, and scientific conferences
Contribute to publications, patents, and company visibility

Qualifications

Education & Experience

PhD (or equivalent) in Molecular Biology, Genetics, Neuroscience, or related field
8–12+ years of experience in early-stage biotech/pharma, with progressive scientific leadership roles
Strong expertise in:
- RNA biology and/or translation mechanisms
- Gene therapy, particularly AAV-based delivery
- Neuromuscular or rare genetic diseases

Technical Expertise

Proven experience with:
- AAV vector design, delivery, and analytics
- LNP delivery modalities
- Preclinical models (rodent; NHP experience is a plus)
- Molecular and cellular assays (RNA-seq, qPCR, histology, biomarkers)
Track record advancing programs toward IND-enabling stages

Leadership & Impact

Demonstrated ability to:
- Translate early science into therapeutic development pipelines
- Lead cross-functional collaborations in a startup or high-growth environment
- Contribute to strategy, fundraising, and partnerships

Additional Strengths

Entrepreneurial mindset with hands-on execution
Strong communication and stakeholder management skills
Experience in rare diseases or platform-based therapeutics is highly preferred

Why Join XtRNA Bio?

Pioneer a new therapeutic modality: tRNA-based medicine
Work on a platform with broad applicability, shifting from "one gene–one drug" to "one mechanism–many diseases."
Directly shape a company advancing toward first-in-human studies
Collaborate with leading scientists and experienced biotech entrepreneurs
Play a central role in delivering transformative therapies for patients with unmet needs

Role Evolution

This role is designed to grow into a Chief Scientific Officer (CSO) or equivalent executive leadership position as the company scales.

Direkt bewerben

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