Research Associate – Peptide Chemistry (m/f/d)
At Enamine Germany, we are building a diverse and dedicated team of chemists to support our partners from academia, the pharmaceutical industry, and the agrochemical sector through high-quality custom synthesis services.
The Position
We are looking for a Research Associate in Peptide Chemistry to join our synthetic organic and peptide chemistry labs in Frankfurt am Main. The role centers on solid phase peptide synthesis (SPPS) and HPLC purification, and is ideal for chemistry professionals who enjoy practical lab work and are passionate about contributing to applied research through hands-on synthesis.
This Team awaits you:
You’ll be part of an international team of around 40 colleagues at our site in Industriepark Höchst in a modern, open space laboratory. We have a motivating, collaborative work environment and support each other with theoretical knowledge and hands-on experience. Everyone’s contribution counts.
Your responsibilities will include:
- Performing lab-scale peptide and small-molecule syntheses, HPLC purification, and quality control of custom molecules
- Operating and maintaining the equipment and software needed for synthesis and purification
- Conducting routine analytical tasks using HPLC-MS and NMR, and evaluating the results
- Contributing to the evaluation and optimization of synthetic and purification processes
- Documenting your work thoroughly and accurately
What You Bring
You’re a great fit for this role if you enjoy working in a lab, have a solid understanding of and interest in organic chemistry, and like to see the direct impact of your efforts. Ideally, you bring:
- Completed studies in chemistry (MSc, or BSc), or completed training as a lab technician (e.g. Chemielaborant:in, CTA, or a comparable technical laboratory qualification);
- Previous industrial experience in a biopharmaceutical company or CRO is advantageous.
- You are experienced in independently planning and performing preparative organic syntheses at lab scale and are ready to faithfully follow routine protocols.
- Hands-on experience in solid phase peptide synthesis (SPPS) — manual and/or automated — is essential for this role; additional experience in parallel chemistry and/or high throughput experimentation is an advantage.
- You have solid working knowledge of HPLC for both preparative purification and analytical characterization, together with foundational knowledge of further analytical methods (HPLC-MS, NMR);
- You are eager to familiarize yourself with new instruments and software and operating them confidently, adapt new chemistry techniques/methods, learn and grow.
- Safe handling of various hazardous substances is routine for you.
- You work in a dedicated, precise, and reliable manner and thoroughly handle the necessary documentation tasks.
- You have a strong sense of responsibility when it comes to working in compliance with relevant regulations in the areas of occupational safety, environmental protection, and quality assurance.
- You are a team player with good communication skills and enjoy a collaborative work environment.
- Excellent English and/or German language skills are an advantage.
Please note: This role is best suited for candidates who enjoy hands-on lab work. If your background is more research-theoretical or strongly academic (e.g., PhD holders), this position may not align with your professional goals.
The position is to be filled promptly. We will interview on an ongoing basis, so please submit your application as soon as possible.
Application Documents
Please send us:
- Your CV
- A motivation letter (max. one page)
- A copy of your highest degree or vocational certificate
Inclusivity & Accessibility
We welcome applicants of all backgrounds and are committed to building an inclusive workplace. Everyone is encouraged to apply—regardless of gender, background, age, religion, disability, or identity.
Please note that the workplace is not fully accessible (barrierefrei). If you have specific accessibility needs, feel free to contact us—we are happy to explore possible solutions together.
About Enamine – Advancing Drug Discovery Together
Founded in 1991, Enamine has grown into a leading global provider of screening compounds, building blocks, and fragment libraries, supporting early drug discovery efforts worldwide. With decades of experience and a strong foundation in medicinal and synthetic chemistry, we collaborate with pharmaceutical and biotech companies, academic institutions, and research centers to accelerate innovation in the life sciences.
In 2023, we expanded our presence to Frankfurt am Main, establishing a dynamic site focused on:
· FTE chemistry support
· Custom synthesis
· Medicinal chemistry services – including Hit-to-Lead optimization, SAR studies, and route scouting
Our international team in Frankfurt consists of around 30 highly skilled scientists, covering diverse areas of modern synthetic chemistry. We specialize in the design and synthesis of complex small molecules, focused compound libraries, peptidomimetics, and macrocycles, combining conventional wet chemistry with innovative parallel synthesis techniques.
At Enamine, we value scientific excellence, collaboration, and creativity. Our Frankfurt team offers a unique opportunity to work at the forefront of drug discovery in a fast-paced, collaborative, and supportive environment.
Welcome to the world of contract research
As a CRO in the chemical industry, we operate at the intersection of science, industry, and society. Our company culture fosters an environment where scientific excellence, teamwork, and personal growth naturally go hand in hand.
What you can expect from us:
· Innovation meets precision: We encourage creative thinking and the use of new technologies – always with a commitment to the highest quality and scientific integrity.
· Teamwork: Our interdisciplinary teams collaborate closely with clients from pharma, biotech, and industry. Commitment, accountability, and open communication matter more than titles or hierarchy.
· Safe & agile: Even within a regulated environment, we work with agile processes, flexible structures, and short decision paths – with a clear focus on safety, compliance, and efficiency.
· Knowledge grows with people: We care about your development. That’s why we invest in training, mentoring, and professional exchange.
· Responsibility for people & planet: Sustainability, lab and workplace safety, and ethical conduct are not extras – they are essential to who we are.
· Diversity drives progress: Everyone is welcome here – regardless of origin, gender, age, or background. Different perspectives make us stronger.
Job Types: Full-time, Contract, Permanent
Pay: 3.800,00€ - 5.400,00€ per month
Ability to commute/relocate:
- 65926 Frankfurt am Main: Reliably commute or planning to relocate before starting work (Preferred)
Education:
Language:
Work Location: In person
