7 beste Stellen als working student it in frankfurt am main, he – aktuell auf Personalsuche

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Doctoral Researcher in Cancer Immunology

Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus
Frankfurt am Main

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Doktorat
Master

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05.05.2026 | Kiss

We are seeking a Doctoral Researcher to join the lab of Dr. Máté Kiss at the Georg-Speyer-Haus Institute for Tumor Biology and Experimental Therapy, studying the regulatory mechanisms controlling neutrophil function in cancer.

The Georg-Speyer-Haus in Frankfurt am Main, Institute for Tumor Biology and Experimental Therapy, is an academic non-profit research institute supported by the Federal Ministry of Health and the Hessian Ministry of Science and Research, Arts and Culture. The institute is dedicated to basic and translational cancer research in the context of the tumor microenvironment and closely cooperates with the Goethe University Frankfurt and the Frankfurt University Hospital. It provides access to a broad variety of core facilities and an excellent scientific environment.

We are seeking a Doctoral Researcher to join the lab of Dr. Máté Kiss at the Georg-Speyer-Haus Institute for Tumor Biology and Experimental Therapy, studying the regulatory mechanisms controlling neutrophil function in cancer.

Project description

Our lab will investigate the interactions between cancer and neutrophils, one of the most common immune cells in the human body which remain unexploited for cancer therapy. Tumors can reprogram neutrophils toward pro-tumoral functions, whereas cancer immunotherapy can elicit a beneficial neutrophil response that supports tumor control. Our goal is to understand how specific signaling pathways and transcription factors drive these opposing neutrophil fates. We aim to identify regulatory circuits that establish tumor-specific maladaptive neutrophil states and test whether disrupting key regulators can repolarize neutrophils to limit tumor progression. In parallel, we aim to elucidate how cancer immunotherapy primes an anti-tumor neutrophil fate and identify regulators whose perturbation can enhance this beneficial neutrophil response.

We will use CRISPR-based genetic perturbations in vitro and in vivo in neutrophil progenitors to identify regulatory circuits that control neutrophil fate and function. To study specific signaling pathways, we will combine analysis of patient samples, mouse tumor models, gene editing in human neutrophil progenitors, transcriptomic, epigenomic and proteomic profiling, as well as flow cytometry and histological analyses.

Requirements

Master’s degree in biomedical sciences, bioengineering or related fields
Proficiency in written and spoken English
Hands-on experience in basic molecular biology techniques, cell culture and flow cytometry
Experience in mouse models and certified training in animal experimentation is a plus
Experience in bioinformatic analyses (e.g. RNA-seq, ATAC-seq) and R programming is a plus

We offer

Access to state-of-the-art facilities at the institute and on campus
A nourishing research environment with institutional research seminars and invited speaker lectures
Possibility of participation in national and international conferences
Structured training program within the framework of the Paul Ehrlich Graduate School for Tumor Biology (https://georg-speyer-haus.de/en/forschung/graduate-school)
PhD project supported by a Thesis Advisory Committee
Career development support, scientific and professional skills courses provided by the institute and by the Goethe University Frankfurt
Lively PhD community with regular scientific networking activities and social events for PhD students
A salary in accordance with the agreement for public service of the state of Hesse (E13, 65%), including social benefits, available for 3 years with the option for extension

Interested?

Applications in English should be submitted electronically to [email protected] as a single PDF containing a cover letter, CV, the names and contact details of at least two references, and academic transcripts from both the bachelor's and master's degrees.

Applications will be reviewed on a rolling basis, and the call will be closed once the position is filled. Therefore, we encourage candidates to apply early.

Start date:

Summer of 2026

Our international working environment promotes equal opportunities for all staff regardless of gender, age, cultural background, nationality or impairments under criteria of scientific excellence. Applications from women are explicitly welcome. Disabled individuals will be preferred in case of equal qualification.

For information about the Georg-Speyer-Haus please visit our website. Follow us on LinkedIn.

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