Start of work:
01.09.2026
Application deadline:
23.06.2026
Tasks
- Lead and execute a research project investigating the effects of pembrolizumab on mitochondrial metabolic reprogramming in macrophages in the context of penile squamous cell carcinoma
- Establish and optimize advanced in vitro models using patient-derived penile cancer cells and human monocytes/macrophages, including monocyte isolation, differentiation, co-culture and conditioned media approaches
- Perform comprehensive functional analyses of macrophages and in‑depth mitochondrial assessments
- Contribute to high‑resolution proteomic and phosphoproteomic studies and actively participate in data processing, bioinformatic analysis and biological interpretation
- Promote the dissemination of research findings by producing high-quality peer-reviewed manuscripts, including the presentation of results at national and international conferences
- Play an active role in the strategic development of the research program by contributing to the acquisition of third‑party funding
Profile
- Extensive experience in mammalian cell culture, ideally including immune cells (monocytes / macrophages) and tumor cell lines; handson work with primary human cells is a strong advantage
- Proven expertise in immunological and molecular techniques (e.g. flow cytometry, ELISA, qRTPCR, Western blotting); experience with advanced methods such as cell sorting, highparameter flow cytometry or RNAseq is desirable
- Strong scientific track record, documented by first and / or lastauthor publications in peerreviewed international journals, and demonstrable experience in drafting manuscripts and revising them in response to peer review
- Documented experience in acquiring thirdparty funding or a clear commitment and aptitude to develop competitive grant applications
- Pronounced interest in tumor immunology, immunometabolism and mitochondrial biology; previous research experience in one or more of these areas is a significant plus
- Independent, wellstructured and reliable working style, combined with a high level of motivation and enthusiasm for collaborative, interdisciplinary and international research
- Excellent written and spoken English
Benefits
- A scientifically stimulating, interdisciplinary environment at a leading university medical center with close links to the clinic, research laboratories and core facilities
- An innovative research project at the interface of tumor immunology, metabolism and oncology with clear clinical relevance
- Opportunities for independent scientific work, publishing and profile development towards an academic career
- Collaboration within a committed, supportive team with flat hierarchies
About us
The University Hospital of Tübingen is a leading center of German university medicine. Every year, around 75,000 inpatients and around 380,000 outpatients are treated. With over 11,000 employees, it is the largest employer in the region. The quality of patient care is certified with the KTQ seal of approval.
About the laboratory of the Department of Urology
Our laboratory is located at the Department of Urology, University Hospital Tübingen. Our research focuses on tumor immunology, mitochondrial dysfunction, and mechanisms of drug repurposing and therapy resistance, with a particular emphasis on identifying actionable targets for translational approaches.
Contact for questions
Mrs. PD Dr. Maria Luisa Barcena
Online application to
Mrs. PD Dr. Maria Luisa Barcena
Index number: 7569
Including CV and cover letter
Application deadline: 23.06.2026
Apply now
WhatsApp application
We offer remuneration in accordance with TV-L (collective wage agreement for the Public Service of the German Federal States), severely handicapped persons with equal qualifications are given preferential consideration. Interview expenses are not covered. Please note the applicable vaccination regulations. The employer actively promotes equal opportunities and particularly encourages applications from women.
1 Continued employment will be sought whereever possible.
2 The data provided does not constitute a basis for an employment contract at the University Hospital of Tübingen. It is intended to serve as a rough guide for all interested parties. Remuneration is governed by the applicable collective bargaining agreements in conjunction with the corresponding pay scales. Further information can be found here.
