Dissecting genomic and post-transcriptional processes and their dynamics in pancreatitis and pancreatic cancer.
Our research focuses on genomic and post-transcriptional processes that facilitate tumor evolution, tumor heterogeneity, metastasis, and drug resistance in cancer. We aim to understand the dynamics of genome editing on the DNA and RNA level, cellular signaling, and their impact on the microenvironment in the context of inflammatory diseases and cancer. We employ cutting-edge computational biology methods to identify genomic aberrations, mutations, and post-transcriptional processes. In addition, we aim to verify those findings functionally and mechanistically with various molecular biology assays using a broad range of in vitro and in vivo platforms, including genetically engineered 2D/3D cell-, organoid- and mouse models, and human specimens.
Our overall goal is to gain a better mechanistic understanding that can be leveraged to identify novel treatment approaches to improve the clinical outcome in patients with inflammatory diseases and cancer. Our lab is currently growing to establish versatile cancer genomics, proteomics, and cell biology platforms to make an impact on the development of novel therapies.
