Maintaining a precise balance of protein synthesis—proteostasis—is fundamental to neuronal health and function. In psychiatric and neurodegenerative diseases, however, this balance is often compromised. Disruptions in translation accuracy, ribosome assembly, and protein degradation are increasingly recognized as critical factors that drive or exacerbate disease progression.
Join our research team in a voluntary and unpaid role for a 6-month Master’s thesis to explore these mechanisms firsthand using patient-derived iPSC models. Your project will bridge the gap between structural ribosome characterization and functional protein dynamics in disorders such as Major Depression and Parkinson’s Disease. By investigating ribosome abundance, cellular localization, and assembly—paired with advanced protein labeling to track the turnover rates of candidates like α-Synuclein—you will help uncover the molecular dysregulations of these conditions.
If the candidates’ suitability for the position in question is equal, severely disabled applicants shall be given preference. Interview-related costs can, unfortunately, not be reimbursed.
