Ihre Aufgaben
Study the functional effect of endogenous β-adrenergic receptors localization in cardiomyocytes;
Design, cloning and testing HaloTag membrane anchored constructs in HEK cells and hiPSC-derived cardiomyocytes to target specific subcellular compartments;
Functional readout of hiPSC-derived cardiomyocytes and isometric force measurements of ventricular slices from mice and humans;
Explore combination of light actuators (opsins and photoswitches) with fluorescent sensors for all-optical experiments;
Conduct an independent research project within a collaborative team;
Present and communicate research results at national and international scientific meetings;
Supervision of students.
Ihre Qualifikationen
You are a curious and enthusiastic scientist who can work independently but also in a team.
Strong background in cardiac physiology and molecular biology.
Applicants should hold a PhD in the life sciences, such as molecular medicine, biology, chemistry, or a related subject.
Fluent English language skills (written and spoken) are required.
Experience with cell culture techniques, microscopy and analyzing large dataset are desirable.
Experience working with laboratory animals; accreditation/certification for animal experimentation is desirable.
Wir bieten
You will work in a high-impact research field with biomedical relevance embedded in the collaborative environment of the Göttingen Campus including several supportive facilities and inspiring research consortia.
Small, international and diverse research group with a strong team spirit and an open-minded, collaborative and respectful working atmosphere.
The UMG is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.
We further strive for gender and diversity equality. We welcome applications from all backgrounds
Einleitungstext
Adrenergic signaling network
β-adrenergic receptors (β-AR) are G-protein coupled receptors (GPCR) that relay sympathetic activity from the autonomic nervous system to the heart primarily via Gs-mediated signalling. The induced physiological changes are summed up as the “fight-or-flight” response to prepare our body for dangerous situations and strong emotions like pain, fear or anger.
Our research focus on the functional role of β-adrenergic receptors in individual nanodomains and their role in the inter-organ communication between heart and brain.
Specifically, we will address two main questions. First, how individual nanodomains contribute to specific functional outputs in cardiomyocytes, and when and how these domains interact with each other. Second, how spatially and temporary defined β-adrenergic receptor signaling patterns in the heart are encoded by cardiac afferents and processed within brain circuits.
About us
Our research group at the University Medical Center Göttingen (UMG) explores β-adrenergic signaling in cardiovascular physiology using photopharmacology and optogenetic stimulation to dissect subcellular network and inter-organ communication between the heart and the brain. Funding for this position is provided by the “UMG2032 - Excellence through Focus” project, funded by zukunft.niedersachsen, the joint science funding program of the Lower Saxony Ministry of Science and Culture and the Volkswagen Foundation.
