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We are looking for an enthusiastic Postdoc/PhD to join our research group to study gene regulation in neurodevelopment with a focus on how NR2F1 dosage shapes the specification of neuronal lineages and the formation of cortical circuits.

NR2F1 is a key transcription factor controlling embryonic neuronal development. Mutations and deletions of NR2F1 lead to Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS). Using neuronal cells derived from CRISPR/Cas9 engineered human induced pluripotent stem cells (hiPSC) we model distinct NR2F1 dosages to study their effects across neuronal differentiation. By integrating time-resolved bulk (RNA-seq, ATAC-seq, ChIP-seq, Hi-C) obtained from neuronal lineages cultured in 2D cells and single-cell multi-omics (scRNA-seq, scATAC-seq, Multiome) data generated in 3D forebrain dorsal organoids, we aim to map regulatory networks sensitive to NR2F1 expression levels.

Our group studies the fundamental principles of embryonic neuronal development by combining genomics, gene editing, and bioinformatics. We offer an international, dynamic, and supportive research environment that fosters creativity and career growth. The AG Laugsch is embedded within Heidelberg’s excellent computational biology network, fostering close collaborations with experts like Carl Herrmann (Institute of Pharmacy and Molecular Biotechnology), and Julio Saez-Rodriguez (Systems Biomedicine, Institute of Computational Biomedicine. If you are a curiosity-driven researcher who enjoys interdisciplinary teamwork and tackling complex biological questions through data, we would be delighted to hear from you. The application must include your motivation, a brief statement of your scientific interests, contact details from three references, curriculum vitae, separated publication list, and relevant certificates.

https://www.klinikum.uni-heidelberg.de/humangenetik/forschung/ag-laugsch/

Literature:

https://doi.org/10.64898/2026.06.25.734423

https://doi.org/10.64898/2026.05.01.722223

doi: 10.1016/j.stem.2019.03.004.

Job-ID: V000015909
Einsatzgebiet: Institut für Humangenetik
Einsatzort: Heidelberg
Tätigkeitsbereich: Wissenschaft und Lehre
Anstellungsart: Vollzeit
Veröffentlicht: 13.07.2026
Befristung:Befristet (3 Jahre)
Vertrag:TV-L

Ihre Aufgaben

Establish computational pipelines for the analysis and integration of single-cell multi-omics data (scRNA-seq, scATAC-seq, Multiome) to reconstruct gene regulatory networks in 3D forebrain dorsal organoids to determine pathophysiological consequences of aberrant NR2F1 dosage
Design and build an interactive, open-access web platform for visualization and usage of multi-omics datasets
Integrate newly generated data with in-house and publicly available datasets to interpret results in a robust biological context
Ensure reproducibility, data management, and documentation of computational workflows in high-performance computing environments
Collaborate closely with experts in computational biology across the university and affiliated institutes, as well as with experimental researchers (wet lab) in the AG Laugsch, to support accurate data interpretation and integration
Maintain clear documentation of analyses and computational workflows on eLab and provide regular progress reports and updates
Actively participate in regular journal clubs and institute meetings. Present findings at lab meetings and international conferences and contribute to manuscripts and grant applications.

Your Profile

Strong background in bioinformatics or computational biology
Practical experience with omics data pre-processing, pipeline development, and high-performance computing
Proficiency in R or Python, and shell scripting
Interest in gene regulation and developmental biology
Optional previous experience with epigenomic data analysis or gene regulatory network inference
Ability to work independently and collaboratively in a multidisciplinary environment
Excellent written and spoken English skills

What we offer

Collectively agreed remuneration TV-L E13, attractive company pension scheme (VBL)
30 days vacation
Sustainable travel: job ticket
Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
Wide range of health, prevention and sports offers
Possibility to publish scientifically is offered and supported
Regular team meetings
Possibility of doctorate

Kontakt & Bewerbung

For further information please contact Dr. rer. nat. Magdalena Laugsch via e-mail.

Interested?

Applications will be accepted until 31.08.2026 online.

Institut für Humangenetik
Dr. rer. nat. Magdalena Laugsch, Group Leader
Im Neuenheimer Feld 366
69120 Heidelberg
+49 6221 56-39128
[email protected]

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