Within the project “Transform-Me” (supported by the Else Kröner-Fresenius Stiftung), we are investigating how epigenetic changes, particularly DNA methylation patterns, are coordinated across the genome. We anticipate these modifications are coherently modified in trans within epigenetic networks. We want to identify modules and hubs that are co-regulated in aging, development, and particularly in malignant transformation. Furthermore, we aim to modulate these epigenetic networks by epigenetic editing. We are looking for a bioinformatician with a strong background in epigenetic characterization of cell preparations with focus on DNA methylation. We are integrating own and public EPIC Illumina Bead Chip datasets, RNA-seq, ATAC-seq, ChIP-seq, nanopore, and single cell DNAm sequencing datasets.

You can find further information on our research group under: http://www.stemcellbiology.ukaachen.de.

References: Liesenfelder et al., 2025: https://www.nature.com/articles/s43587-025-00841-1

Varona Baranda et al., 2026: https://www.biorxiv.org/content/10.64898/2026.06.05.729844v1

Your tasks:

Integrative analysis of many epigenetic datasets, particularly DNAm profiles from public repositories
Coregulation and network analysis
Machine learning approaches predicting epigenetic patterns
Analysis and integration of chromatin accessibility and histone modifications
Analysis of single cell DNAm datasets
Design and analysis of epigenetic editing experiments
Scientific publication of the results

Your profile:

Master’s degree in either Biology, Bioinformatics, or comparable degrees in Natural Sciences
A successful PhD with bioinformatics on epigenetics or stem cell research
Bioinformatic skills for DNA methylation analysis
programming languages R and optionally perl or python
Knowledge in cancer and aging research
Willingness to contribute to different projects within our team
Able to communicate clearly in English and willing to work in an international team
Relevant scientific publications

Why you should choose us?

We offer…

We provide a highly interactive and well-equipped environment, in an international team, with excellent partners
The research topic is very timely, clinically relevant, and challenging
30 days of vacation per year for full-time employment

Application:

The application deadline for the advertised position GB-P-56328 is August 30, 2026.

Plesae include:

a motivation letter, which specifically emphasizes your interest in this project
CV with publication list
contacts of two references
copies of the most important certificates (with grades)

University Hospital of the RWTH Aachen, Helmholtz Institute for Biomedical Engineering -Institute for Stem Cell Biology-, Head of Division Prof. Wolfgang Wagner, M.D., Ph.D, Pauwelsstr. 30, 52074 Aachen.

Contact:

If you have any questions, please contact Prof. Dr. Dr. Wolfgang Wagner ([email protected]) or Katharina Hayat ([email protected])

We look forward to receive your application.

This job advertisement is aimed at all genders.

The RWTH Aachen University Hospital promotes equal opportunity and diversity. Applications from women are expressly sought and, in accordance with relevant laws, will be treated preferentially.

We welcome applications from people with disabilities and they will be given priority if they are equally suitable.

Employment at a fraction less than the weekly full-time working hours stated above is generally possible.

It is preferable to use our digital application portal at www.karriere.ukaachen.de to apply. The portal allows you to upload your documents to an electronic application folder, which is protected from unauthorized access. Applications received by email are transferred to our application portal and then deleted in accordance with data protection regulations. (Transmission by email is usually inadequately protected.) If you do not agree to the transfer of your data to our portal, we unfortunately cannot consider your application. The data in the portal will be deleted after the retention period has expired.

This job advertisement was created using an AI-supported system. Final content review and responsibility lie with the Universitätsklinikum Aachen.

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