The Department of Internal Medicine II at TUM Klinikum rechts der Isar is recruiting a highly motivated Postdoctoral Researcher to join our newly established Max Eder Research Group.
Our research aims to decipher the molecular mechanisms of tumor evolution, cellular plasticity, and therapy resistance in gastric and gastroesophageal adenocarcinoma (GEAC). By integrating longitudinal patient samples from prospective clinical trials with cutting-edge multi-omics technologies and functional model systems, our group is committed to understanding the biological mechanisms underlying treatment resistance in upper gastrointestinal cancers and translating these discoveries into novel therapeutic strategies.
The position offers the unique opportunity to work at the interface of clinical oncology, cancer genomics, computational biology, and functional cancer research within an outstanding translational research environment.
You will investigate the molecular mechanisms of tumor evolution, cellular plasticity, and therapy resistance in GEAC through the integration of longitudinal multi-omics datasets from prospective clinical trial samples.
Your research will focus on computational analysis and interpretation of large-scale molecular datasets, including:
- Analysis and integration of single-cell and spatial transcriptomic datasets to characterize tumor evolution and treatment response
- Inference of tissue-specific gene expression and tumor activity from plasma cell-free DNA fragmentation patterns
- Development of computational approaches for the integration of genomic, transcriptomic, epigenomic and immune profiling data
- Multi-omics integration to reconstruct tumor evolutionary trajectories and characterize cellular plasticity during treatment
- Development and implementation of bioinformatic pipelines for high-dimensional sequencing datasets
- Close collaboration with clinicians, biologists, computational biologists and international collaborators
- Presentation of research at international conferences and publication in high-impact scientific journals
If the candidates’ suitability for the position in question is equal, severely disabled applicants shall be given
preference.
Interview-related costs can, unfortunately, not be reimbursed.
